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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-5-8
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pubmed:abstractText |
Secondary bacterial infection often occurs after pulmonary virus infection and is a common cause of severe disease in humans, yet the mechanisms responsible for this viral-bacterial synergy in the lung are only poorly understood. We now report that pulmonary interferon-gamma (IFN-gamma) produced during T cell responses to influenza infection in mice inhibits initial bacterial clearance from the lung by alveolar macrophages. This suppression of phagocytosis correlates with lung IFN-gamma abundance, but not viral burden, and leads to enhanced susceptibility to secondary pneumococcal infection, which can be prevented by IFN-gamma neutralization after influenza infection. Direct inoculation of IFN-gamma can mimic influenza infection and downregulate the expression of the class A scavenger receptor MARCO on alveolar macrophages. Thus, IFN-gamma, although probably facilitating induction of specific anti-influenza adaptive immunity, suppresses innate protection against extracellular bacterial pathogens in the lung.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/CD8 antigen, alpha chain,
http://linkedlifedata.com/resource/pubmed/chemical/Complement C3,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Marco protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/interferon gamma receptor
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1546-170X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
558-64
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pubmed:dateRevised |
2011-5-10
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pubmed:meshHeading |
pubmed-meshheading:18438414-Analysis of Variance,
pubmed-meshheading:18438414-Animals,
pubmed-meshheading:18438414-Antigens, CD4,
pubmed-meshheading:18438414-Antigens, CD8,
pubmed-meshheading:18438414-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:18438414-Complement C3,
pubmed-meshheading:18438414-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18438414-Immunity, Innate,
pubmed-meshheading:18438414-Interferon-gamma,
pubmed-meshheading:18438414-Interleukin-10,
pubmed-meshheading:18438414-Lung,
pubmed-meshheading:18438414-Macrophages,
pubmed-meshheading:18438414-Mice,
pubmed-meshheading:18438414-Mice, Inbred BALB C,
pubmed-meshheading:18438414-Mice, Inbred C57BL,
pubmed-meshheading:18438414-Mice, Knockout,
pubmed-meshheading:18438414-Microscopy, Fluorescence,
pubmed-meshheading:18438414-Orthomyxoviridae Infections,
pubmed-meshheading:18438414-Pneumococcal Infections,
pubmed-meshheading:18438414-Receptors, Immunologic,
pubmed-meshheading:18438414-Receptors, Interferon
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pubmed:year |
2008
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pubmed:articleTitle |
Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection.
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pubmed:affiliation |
Center for Immunology & Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, New York 12208, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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