Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-7-21
pubmed:abstractText
This study was conducted to investigate effects of an acute sodium load on resting plasma volume (PV) and renal mechanisms across the menstrual cycle of endurance-trained women with natural (NAT) or oral contraceptive pill (OCP) controlled cycles. Twelve women were assigned to one of two groups, according to their usage status: 1) OCP [n = 6, 29 yr (SD 6), 59.4 kg (SD 3.2)], or 2) NAT [n = 6, 24 yr (SD 5), 61.3 kg (SD 3.6)]. The sodium load was administered as a concentrated sodium chloride/citrate beverage (164 mmol Na(+)/l, 253 mosmol/kgH(2)O, 10 ml/kg body mass) during the last high-hormone week of the OCP cycle (OCP(high)) or late luteal phase of the NAT cycle (NAT(high)) and during the low-hormone sugar pill week of OCP (OCP(low)) or early follicular phase of the NAT cycle (NAT(low)). The beverage ( approximately 628 ml) was ingested in seven portions across 60 min. Over the next 4 h, PV expanded more in the low-hormone phase for both groups (time-averaged change): OCP(low) 6.1% (SD 1.1) and NAT(low) 5.4% (SD 1.2) vs. OCP(high) 3.9% (SD 0.9) and NAT(high) 3.5% (SD 0.8) (P = 0.02). The arginine vasopressin increased less in the low-hormone phase [1.63 (SD 0.2) and 1.30 pg/ml (SD 0.2) vs. 1.82 (SD 0.3) and 1.57 pg/ml (SD 0.5), P = 0.0001], as did plasma aldosterone concentration ( approximately 64% lower, P = 0.0001). Thus PV increased more and renal hormone sensitivity was decreased in the low-hormone menstrual phase following sodium/fluid ingestion, irrespective of OCP usage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-7
pubmed:meshHeading
pubmed-meshheading:18436693-Adult, pubmed-meshheading:18436693-Arginine Vasopressin, pubmed-meshheading:18436693-Bicycling, pubmed-meshheading:18436693-Body Water, pubmed-meshheading:18436693-Contraceptives, Oral, Hormonal, pubmed-meshheading:18436693-Electrolytes, pubmed-meshheading:18436693-Ethinyl Estradiol, pubmed-meshheading:18436693-Female, pubmed-meshheading:18436693-Follicular Phase, pubmed-meshheading:18436693-Gonadal Steroid Hormones, pubmed-meshheading:18436693-Hormones, pubmed-meshheading:18436693-Humans, pubmed-meshheading:18436693-Kidney, pubmed-meshheading:18436693-Levonorgestrel, pubmed-meshheading:18436693-Luteal Phase, pubmed-meshheading:18436693-Models, Statistical, pubmed-meshheading:18436693-Osmotic Pressure, pubmed-meshheading:18436693-Plasma Volume, pubmed-meshheading:18436693-Progestins, pubmed-meshheading:18436693-Rest, pubmed-meshheading:18436693-Sodium
pubmed:year
2008
pubmed:articleTitle
Endogenous and exogenous female sex hormones and renal electrolyte handling: effects of an acute sodium load on plasma volume at rest.
pubmed:affiliation
School of Physical Education, University of Otago, Dunedin, New Zealand. stsims@stanford.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't