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rdf:type |
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lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0021761,
umls-concept:C0027627,
umls-concept:C0027651,
umls-concept:C0205195,
umls-concept:C0254610,
umls-concept:C0301872,
umls-concept:C0677798,
umls-concept:C0920725,
umls-concept:C1458155,
umls-concept:C1512954,
umls-concept:C1527148
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pubmed:issue |
3
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pubmed:dateCreated |
2009-2-27
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pubmed:abstractText |
Tumor development or recurrence is always a matter of concern following radiofrequency thermal ablation (RFA) of tumors. To determine whether combining RFA with immunologically active cytokines might induce tumor-specific immune responses against mammary carcinoma and inhibit tumor development or metastasis, we evaluated intralesional injection of IL-7 and IL-15 in RFA-treated murine tumors. We used two different breast carcinoma models: neu-overexpressing mouse mammary carcinoma (MMC) in FVBN202 transgenic mouse and 4T1 tumors in Balb/c mouse. MMC tend to relapse even in the presence of neu-specific immune responses, and 4T1 is a weakly immunogenic, aggressive and highly metastatic transplantable tumor. In vivo growth of both of these tumors is also associated with increased numbers of CD11b+Gr1+ myeloid-derived suppressor cells (MDSC). We showed for the first time that unlike RFA alone, RFA combined with the administration of intralesional IL-7 and IL-15 (after RFA), induced immune responses to tumors, inhibited tumor development and lung metastasis, and reduced MDSC.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-10522847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-11062503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-12364820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-12669018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-12759473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-1342368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-1359541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-14625547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-14871850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-14990810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-15044705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-15173017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-15492286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-15687613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-15841203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-16211331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-16240062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-16288050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-16424051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-16767940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-16818678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-16849459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-16849578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-16868550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-16953240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-17106716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-17116643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-17159986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-17227896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-17255288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-17304628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-17577033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18425677-9537252
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1573-7217
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
423-31
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18425677-Animals,
pubmed-meshheading:18425677-Antineoplastic Agents,
pubmed-meshheading:18425677-Catheter Ablation,
pubmed-meshheading:18425677-Female,
pubmed-meshheading:18425677-Immune System,
pubmed-meshheading:18425677-Immunotherapy,
pubmed-meshheading:18425677-Interferon-gamma,
pubmed-meshheading:18425677-Interleukin-15,
pubmed-meshheading:18425677-Interleukin-7,
pubmed-meshheading:18425677-Mammary Neoplasms, Animal,
pubmed-meshheading:18425677-Mice,
pubmed-meshheading:18425677-Mice, Inbred BALB C,
pubmed-meshheading:18425677-Mice, Transgenic,
pubmed-meshheading:18425677-Neoplasm Metastasis,
pubmed-meshheading:18425677-Rats
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pubmed:year |
2009
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pubmed:articleTitle |
Radiofrequency thermal ablation of breast tumors combined with intralesional administration of IL-7 and IL-15 augments anti-tumor immune responses and inhibits tumor development and metastasis.
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pubmed:affiliation |
Department of Microbiology and Immunology, VCU School of Medicine, Massey Cancer Center, 401 College Street, Box 980035, Richmond, VA 23298, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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