Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-4-16
pubmed:abstractText
Hematopoietic stem cells (HSCs) are multipotent progenitors that give rise to all types of blood cells. In the present study, we document that HSC development and functions are negatively regulated by the E3 ubiquitin ligase c-Cbl (casitas B-cell lymphoma). HSCs of c-Cbl(-/-) mice exhibit augmented pool size, hyperproliferation, greater competence, and enhanced long-term repopulating capacity. Our mechanistic studies identified that c-Cbl(-/-) HSCs are hyperresponsive to thrombopoietin (TPO) and display elevated levels of STAT5 phosphorylation, thus leading to increased c-Myc expression. In essence, our data unequivocally identify c-Cbl as a novel negative regulator of developmental and functional properties of HSCs.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-10068671, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-10514377, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-10617633, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-10635327, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-10679091, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-10834841, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-11239464, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-11283727, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-11777909, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-11786953, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-12048235, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-12193575, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-14499658, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-15032575, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-15067010, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-15315962, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-15334084, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-15345216, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-15457182, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-15989959, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-15998795, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-16211006, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-16227975, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-16406635, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-16574858, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-16715089, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-16810242, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-18413709, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-2784003, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-8689561, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-9448308, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-9671496, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-9759494, http://linkedlifedata.com/resource/pubmed/commentcorrection/18413713-9861006
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0890-9369
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
992-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.
pubmed:affiliation
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural