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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-5-1
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pubmed:abstractText |
Human epidermal growth factor receptor type 2 (HER2) is a well-established tumor biomarker that is overexpressed in a wide variety of cancers and that serves as a molecular target for therapeutic intervention. HER2 also serves as a prognostic indicator of patient survival and as a predictive marker of the response to antineoplastic therapy. The development of (18)F-labeled biomolecules for PET imaging of HER2 (HER2 PET) is very important because it may provide a powerful tool for the early detection of HER2-positive tumor recurrence and for the monitoring of HER2-based tumor treatment.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0161-5505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
804-13
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18413392-Animals,
pubmed-meshheading:18413392-Cell Line, Tumor,
pubmed-meshheading:18413392-Dimerization,
pubmed-meshheading:18413392-Fluorine Radioisotopes,
pubmed-meshheading:18413392-Gene Expression Regulation,
pubmed-meshheading:18413392-Halogenation,
pubmed-meshheading:18413392-Humans,
pubmed-meshheading:18413392-Mice,
pubmed-meshheading:18413392-Neoplasms,
pubmed-meshheading:18413392-Positron-Emission Tomography,
pubmed-meshheading:18413392-Protein Binding,
pubmed-meshheading:18413392-Protein Structure, Quaternary,
pubmed-meshheading:18413392-Radiochemistry,
pubmed-meshheading:18413392-Receptor, Epidermal Growth Factor,
pubmed-meshheading:18413392-Recombinant Fusion Proteins,
pubmed-meshheading:18413392-Substrate Specificity,
pubmed-meshheading:18413392-Tissue Distribution
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pubmed:year |
2008
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pubmed:articleTitle |
Small-animal PET imaging of human epidermal growth factor receptor type 2 expression with site-specific 18F-labeled protein scaffold molecules.
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pubmed:affiliation |
Molecular Imaging Program at Stanford, Department of Radiology, Bio-X Program, Stanford University, Stanford, California 94305, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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