Linked Life Data

1840486

Source:http://linkedlifedata.com/resource/pubmed/id/1840486

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-7-31
pubmed:databankReference
pubmed:abstractText
The genetic defect of bilirubin UDP-glucuronosyltransferase (UDPGT) in the hyperbilirubinemic Gunn rat was proved to be a -1 frameshift mutation. The mutation was found not only to be located in the region where bilirubin UDPGT cDNA shared an identical sequence with 3-methylcholanthrene (3M C)-inducible UDPGT cDNA but also to occur in the same position on the two cDNAs from the mutant rat. At the 5' end of the identical region there was a consensus sequence for splicing, of which position coincided with the boundary between the 2nd and 3rd exon of the testosterone UDPGT gene. These results strongly suggest that mRNAs for bilirubin and 3M C-inducible UDPGTs are produced from a single primary-transcript after an alternative splicing and the defects of bilirubin and 3M C-inducible UDPGTs in the mutant rat are caused by a point mutation on a common exon.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
177
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1161-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Genetic defect of bilirubin UDP-glucuronosyltransferase in the hyperbilirubinemic Gunn rat.
pubmed:affiliation
Department of Biology, Shiga University of Medical Science, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't