Linked Life Data

18400910

Source:http://linkedlifedata.com/resource/pubmed/id/18400910

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-6-9
pubmed:abstractText
Laboratory and clinical diagnostic classification of seropositive individuals, followed by treatment and supportive therapy, is an established component of Chagas' disease control in areas where this disease is endemic. However, most Chagas' disease patients live in remote areas where neither equipped laboratories nor skilled human resources are widely available. Employing a rapid diagnostic test (RDT), when using whole blood samples, is the best option for Chagas' disease control. A high sensitivity and specificity for the Chagas Stat-Pak RDT (Chembio Diagnostic Systems, Inc., Medford, NY) has been reported for assays using serum and plasma, but its validity for the detection of antibodies to Trypanosoma cruzi infection in whole blood is unknown. This cross-sectional study measured the sensitivity and specificity of the Chagas Stat-Pak with whole blood, using conventional serological assays for comparison. The interobserver reliability in the interpretation of the Chagas Stat-Pak results and "ease-of-use" criterion needed to perform the Chagas Stat-Pak and conventional assays were also measured. The Chagas Stat-Pak yielded a high specificity (99.0%, 95% confidence interval [CI] = 98.4 to 99.4%) but a relatively low sensitivity (93.4%, 95% CI = 87.4 to 97.1%). The interobserver reliability was excellent (kappa [n = 1,913] = 0.999, P < 0.0001), and the quantified ease-of-use criterion suggested that the RDT is simple to perform. Despite the attributes of the Chagas Stat-Pak, it is not an ideal diagnostic test for the population investigated in the present study due to its relatively low sensitivity and high cost. The RDT manufacturer is called upon to improve the test if the international community hopes to make progress in controlling Chagas infections in areas where this disease is endemic.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-10456995, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-11871482, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-12613761, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-12835217, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-12944018, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-15110206, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-16185616, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-16207963, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-16390983, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-16928995, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-17506881, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-17891274, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-843571, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-8862574, http://linkedlifedata.com/resource/pubmed/commentcorrection/18400910-9790423
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1098-660X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2022-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Field evaluation of a rapid immunochromatographic assay for detection of Trypanosoma cruzi infection by use of whole blood.
pubmed:affiliation
Médecins Sans Frontières Spain, Barcelona, Spain. paul.roddy@barcelona.msf.org
pubmed:publicationType
Journal Article, Evaluation Studies