Prospero-related homeobox 1 (Prox1) transcription factor was described as a tumor-suppressor gene in liver tumors. In contrast, Prox1 knock out in murine embryos drastically reduces proliferation of hepatoblasts.
Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Georg-August-University Goettingen, Robert-Koch-Strasse 40, 37075 Goettingen, Germany. jdudas@gwdg.de <jdudas@gwdg.de>