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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
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|
pubmed:dateCreated |
2008-4-10
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|
pubmed:abstractText |
Torasemide is frequently used for the treatment of hypertension and heart failure. However, the determinants of torasemide pharmacokinetics in patients during steady-state conditions are largely unknown. We therefore explored the impact of genetic polymorphisms of cytochrome P450 (CYP) 2C9 (CYP2C9) and organic anion transporting polypeptide (OATP) 1B1 (SLCO1B1), gender, and the effects of losartan and irbesartan comedication on the interindividual variability of steady-state pharmacokinetics of torasemide.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
0312-5963
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
47
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
323-32
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|
pubmed:meshHeading |
pubmed-meshheading:18399713-Aged,
pubmed-meshheading:18399713-Analysis of Variance,
pubmed-meshheading:18399713-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:18399713-Antihypertensive Agents,
pubmed-meshheading:18399713-Area Under Curve,
pubmed-meshheading:18399713-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:18399713-Calibration,
pubmed-meshheading:18399713-Chromatography, High Pressure Liquid,
pubmed-meshheading:18399713-Dose-Response Relationship, Drug,
pubmed-meshheading:18399713-Drug Interactions,
pubmed-meshheading:18399713-Female,
pubmed-meshheading:18399713-Genotype,
pubmed-meshheading:18399713-Half-Life,
pubmed-meshheading:18399713-Humans,
pubmed-meshheading:18399713-Male,
pubmed-meshheading:18399713-Organic Anion Transporters,
pubmed-meshheading:18399713-Pharmacogenetics,
pubmed-meshheading:18399713-Sex Characteristics,
pubmed-meshheading:18399713-Sulfonamides
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
Determinants of steady-state torasemide pharmacokinetics: impact of pharmacogenetic factors, gender and angiotensin II receptor blockers.
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|
pubmed:affiliation |
Department of Cardiology, Helios-Hospital Schwerin, Schwerin, Germany. dierk.werner@arcor.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|
