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pubmed-article:18398336pubmed:abstractTextRegulator of G-protein signaling (RGS)-2 is a regulator of angiotensin II (Ang II) signaling. In Bartter's syndrome/Gitelman's syndrome (BS/GS), we have demonstrated increased RGS-2 levels and blunted Ang II signaling which contribute to their reduced vasomotor tone and remodeling. The present study investigates the effect of silencing RGS-2 in fibroblasts from six BS/GS patients on intracellular Ca2+ (CaI2+) mobilization and extracellular signal-regulated kinase (ERK) 1/2 phosphorylation, established Ang II-mediated responses.lld:pubmed
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pubmed-article:18398336pubmed:articleTitleSilencing regulator of G protein signaling-2 (RGS-2) increases angiotensin II signaling: insights into hypertension from findings in Bartter's/Gitelman's syndromes.lld:pubmed
pubmed-article:18398336pubmed:affiliationDepartment of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Padova, Italy. renzcalo@unipd.itlld:pubmed
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