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rdf:type |
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lifeskim:mentions |
umls-concept:C0003009,
umls-concept:C0020538,
umls-concept:C0037083,
umls-concept:C0039082,
umls-concept:C0086376,
umls-concept:C0233820,
umls-concept:C0442805,
umls-concept:C1704735,
umls-concept:C1710082,
umls-concept:C2607943,
umls-concept:C2926606
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pubmed:issue |
5
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|
pubmed:dateCreated |
2008-4-9
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pubmed:abstractText |
Regulator of G-protein signaling (RGS)-2 is a regulator of angiotensin II (Ang II) signaling. In Bartter's syndrome/Gitelman's syndrome (BS/GS), we have demonstrated increased RGS-2 levels and blunted Ang II signaling which contribute to their reduced vasomotor tone and remodeling. The present study investigates the effect of silencing RGS-2 in fibroblasts from six BS/GS patients on intracellular Ca2+ (CaI2+) mobilization and extracellular signal-regulated kinase (ERK) 1/2 phosphorylation, established Ang II-mediated responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0263-6352
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
938-45
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18398336-Adult,
pubmed-meshheading:18398336-Angiotensin II,
pubmed-meshheading:18398336-Bartter Syndrome,
pubmed-meshheading:18398336-Calcium,
pubmed-meshheading:18398336-Cells, Cultured,
pubmed-meshheading:18398336-Cohort Studies,
pubmed-meshheading:18398336-Female,
pubmed-meshheading:18398336-Fibroblasts,
pubmed-meshheading:18398336-Gene Silencing,
pubmed-meshheading:18398336-Gitelman Syndrome,
pubmed-meshheading:18398336-Humans,
pubmed-meshheading:18398336-Male,
pubmed-meshheading:18398336-Middle Aged,
pubmed-meshheading:18398336-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:18398336-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:18398336-Phosphorylation,
pubmed-meshheading:18398336-RGS Proteins,
pubmed-meshheading:18398336-Signal Transduction
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pubmed:year |
2008
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pubmed:articleTitle |
Silencing regulator of G protein signaling-2 (RGS-2) increases angiotensin II signaling: insights into hypertension from findings in Bartter's/Gitelman's syndromes.
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pubmed:affiliation |
Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Padova, Italy. renzcalo@unipd.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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