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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0026900,
umls-concept:C0040648,
umls-concept:C0162741,
umls-concept:C0243125,
umls-concept:C0699900,
umls-concept:C1260957,
umls-concept:C1413724,
umls-concept:C1515877,
umls-concept:C1826738,
umls-concept:C1879547
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pubmed:issue |
3
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pubmed:dateCreated |
2008-8-29
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pubmed:abstractText |
Cryptochromes (CRY) are one of the two major classes of photoreceptors that perceive light stimuli in the UV-A to blue light region and they are involved in multiple aspects of plant growth and development. However, knowledge regarding their signaling transduction components and mechanisms remains limited. Here, we report that a MYB transcription factor Blue Insensitive Trait 1 (BIT1), plays an important role in controlling blue light responses. Hypocotyl growth responses indicate that BIT1 functions as a positive element in blue light signaling, since BIT1 antisense and knock-out lines show a reduced light response in blue light. BIT1 controls blue light-dependent expression of various genes such as PsbS, a member of the light-harvesting complex gene family. A transactivation assay showed that BIT1 regulates promoter activity of PsbS in a blue light-dependent manner and that it requires CRY1 for activation of the PsbS promoter. BIT1 undergoes degradation in darkness and CRY1 functions to stabilize BIT1 in a blue light-dependent manner. In contrast, COP1 binds to BIT1 and mediates its degradation. We propose that the PsbS promoter is activated in blue light via the blue light-dependent stabilization of BIT1 by CRY1, while in darkness BIT1 is degraded by COP1-mediated proteolysis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arabidopsis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/COP1 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/CRY1 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/Cryptochromes,
http://linkedlifedata.com/resource/pubmed/chemical/Flavoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Light-Harvesting Protein Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/NPQ4 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/Photosynthetic Reaction Center...,
http://linkedlifedata.com/resource/pubmed/chemical/Photosystem II Protein Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1365-313X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
361-71
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18397371-Arabidopsis,
pubmed-meshheading:18397371-Arabidopsis Proteins,
pubmed-meshheading:18397371-Cryptochromes,
pubmed-meshheading:18397371-Flavoproteins,
pubmed-meshheading:18397371-Gene Expression Regulation, Plant,
pubmed-meshheading:18397371-Light,
pubmed-meshheading:18397371-Light-Harvesting Protein Complexes,
pubmed-meshheading:18397371-Photosynthetic Reaction Center Complex Proteins,
pubmed-meshheading:18397371-Photosystem II Protein Complex,
pubmed-meshheading:18397371-Promoter Regions, Genetic,
pubmed-meshheading:18397371-Signal Transduction,
pubmed-meshheading:18397371-Transcription Factors,
pubmed-meshheading:18397371-Ubiquitin-Protein Ligases
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pubmed:year |
2008
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pubmed:articleTitle |
CRY1 inhibits COP1-mediated degradation of BIT1, a MYB transcription factor, to activate blue light-dependent gene expression in Arabidopsis.
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pubmed:affiliation |
Division of Molecular and Life Science, POSTECH, Pohang, 790-784, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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