Linked Life Data

1839326

Source:http://linkedlifedata.com/resource/pubmed/id/1839326

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-4-21
pubmed:abstractText
Excitatory response to 5-hydroxytryptamine was recorded from the external carotid nerve, a branch of the superior cervical ganglia, in anesthetized rats using an electrophysiological technique. Bolus intravenous injection of 5-HT (1.5625-50 micrograms/kg) evoked a rapid and dose-dependent excitation of external carotid nerve activity. This response was blocked by a selective 5-HT3-receptor antagonist, GR38032F (10 micrograms/kg). A 5-HT3 receptor agonist, 2-methyl-5-HT (3.125-50 micrograms/kg), also produced a rapid and dose-dependent excitation of external carotid nerve activity. GR38032F (10 micrograms/kg) caused a significant rightward shift in the 2-methyl-5-HT dose-response curve. These results suggest that the 5-HT-induced excitatory response of ECNA might be mediated via a 5-HT3 receptor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-45
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Effect of 5-hydroxytryptamine on external carotid nerve activity and its blockade by GR38032F in anesthetized rats.
pubmed:affiliation
First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan.
pubmed:publicationType
Journal Article