Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-8-7
pubmed:abstractText
Using noninvasive in vivo imaging and experimental autoimmune uveoretinitis as a model, we show for the first time that the mechanisms controlling blood monocyte recirculation through peripheral and lymphoid tissues alter during inflammation. The recirculation of monocytes in mice with ocular inflammation but not controls was found to depend on the selectin CD62-ligand (CD62L) and on CD44. Not only was rolling efficiency ablated or markedly reduced in antibody-treated mice, but most of the labeled monocytes also disappeared from the circulation within seconds, anti-CD44-treated monocytes homing to the lymph nodes and anti-CD62L-treated monocytes homing to the spleen. Our data indicate that, although PSGL-1 has a partial role in the transmigration of monocytes into the inflamed retina, CD62L has a key role in regulating recruitment of monocytes to lymphoid tissue from the blood during inflammation and that CD44 is required to maintain CD62L(+) inflammatory monocytes within the circulation during inflammation. This effect was systemic, because sequestered monocytes accumulated in mesenteric as well as draining cervical lymph nodes, and inflammation dependent, because depletion of circulating blood monocytes was much reduced or absent in normal mice and accumulations of adoptively transferred monocytes in the lymphoid tissues did not occur.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-11523524, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-12014921, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-12068018, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-12207337, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-12488494, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-12506079, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-12645937, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-12736247, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-12796473, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-12871640, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-14634055, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-14978129, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-15021878, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-15032576, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-15034056, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-15173832, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-15611236, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-15743805, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-16272351, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-16365158, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-16369557, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-16415171, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-1688560, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-16920499, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-18684876, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-7505784, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-7515891, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-7522194, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-7528669, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-7530761, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-8538793, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-8683134, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-8757614, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-8977216, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-9103231, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-9281593, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-9292527, http://linkedlifedata.com/resource/pubmed/commentcorrection/18391078-9774276
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1166-74
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation.
pubmed:affiliation
Department of Ophthalmology, University of Aberdeen Institute of Medical Sciences, Aberdeen, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't