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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-6-26
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pubmed:abstractText |
Rates of progression vary widely in primary progressive multiple sclerosis. This multicenter study aimed to identify predictors of progression over 10 years. A total of 101 patients who had been imaged at baseline and 2 years were scored on the expanded disability status scale after 10 years. Ordinal logistic regression identified the following independent variables that predicted progression: male sex, shorter disease duration, and slower timed walk test at baseline (best overall predictor), and deterioration in expanded disability status scale score and reduction in brain volume over 2 years. These predictors of long-term disability provide some insight into disease progression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1531-8249
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pubmed:author |
pubmed-author:BarkhofFrederikF,
pubmed-author:BrochetBrunoB,
pubmed-author:CercignaniMaraM,
pubmed-author:CiccarelliOlgaO,
pubmed-author:DoussetVincentV,
pubmed-author:FilippiMassimoM,
pubmed-author:KhaleeliZhalehZ,
pubmed-author:ManfredoniaFrancescoF,
pubmed-author:MillerDavidD,
pubmed-author:MontalbanXavierX,
pubmed-author:PolmanChrisC,
pubmed-author:RovarisMarcoM,
pubmed-author:RoviraAlexA,
pubmed-author:Sastre-GarrigaJaumeJ,
pubmed-author:ThompsonAlanA,
pubmed-author:VellingaMachteldM
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pubmed:issnType |
Electronic
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
790-3
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pubmed:dateRevised |
2011-11-4
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pubmed:meshHeading |
pubmed-meshheading:18383506-Adult,
pubmed-meshheading:18383506-Aged,
pubmed-meshheading:18383506-Atrophy,
pubmed-meshheading:18383506-Brain,
pubmed-meshheading:18383506-Disability Evaluation,
pubmed-meshheading:18383506-Disease Progression,
pubmed-meshheading:18383506-Female,
pubmed-meshheading:18383506-Gait Disorders, Neurologic,
pubmed-meshheading:18383506-Humans,
pubmed-meshheading:18383506-Longitudinal Studies,
pubmed-meshheading:18383506-Magnetic Resonance Imaging,
pubmed-meshheading:18383506-Male,
pubmed-meshheading:18383506-Middle Aged,
pubmed-meshheading:18383506-Multiple Sclerosis, Chronic Progressive,
pubmed-meshheading:18383506-Predictive Value of Tests,
pubmed-meshheading:18383506-Prognosis,
pubmed-meshheading:18383506-Risk Factors,
pubmed-meshheading:18383506-Sex Distribution,
pubmed-meshheading:18383506-Spinal Cord,
pubmed-meshheading:18383506-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter study.
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pubmed:affiliation |
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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