| pubmed-article:18381066 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18381066 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18381066 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:18381066 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:18381066 | lifeskim:mentions | umls-concept:C1563743 | lld:lifeskim |
| pubmed-article:18381066 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:18381066 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:18381066 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18381066 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:18381066 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18381066 | pubmed:dateCreated | 2008-4-28 | lld:pubmed |
| pubmed-article:18381066 | pubmed:abstractText | To assess the metabolic effects of chronic activation of AMP-activated protein kinase (AMPK) in liver, we generated a new transgenic (Tg) mouse model expressing constitutively active (CA)-AMPK-alpha1 in liver. In the short-term activation, the TgCA-AMPK-alpha1 mice exhibited minimal phenotype, but the Tg liver had elevated sterol regulatory element-binding protein (SREBP)-2 mRNA level and a parallel increase in transcripts of its target genes. UCP2 mRNA level was elevated. In the long-term activation, the TgCA-AMPK-alpha1 mice had markedly reduced white fat mass. The Tg liver had reduced mRNA expression of SREBP-1c and its target genes. Remarkably, the Tg mice were resistant to a high-fat diet-induced obesity. These data suggest that short-term chronic activation of AMPK-alpha1 in liver leads to compensatory increase in lipogenic gene expression due to increased SREBP-2 expression, and long-term chronic activation of AMPK-alpha1 decreases expression of SREBP-1c and its target genes, which results in reduced fat storage. | lld:pubmed |
| pubmed-article:18381066 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18381066 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18381066 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18381066 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18381066 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18381066 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18381066 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18381066 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18381066 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18381066 | pubmed:month | May | lld:pubmed |
| pubmed-article:18381066 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:18381066 | pubmed:author | pubmed-author:YangJianJ | lld:pubmed |
| pubmed-article:18381066 | pubmed:author | pubmed-author:LiuZhi-MeiZM | lld:pubmed |
| pubmed-article:18381066 | pubmed:author | pubmed-author:KingJudy AJA | lld:pubmed |
| pubmed-article:18381066 | pubmed:author | pubmed-author:MaikaShannaS | lld:pubmed |
| pubmed-article:18381066 | pubmed:author | pubmed-author:CraddockLaure... | lld:pubmed |
| pubmed-article:18381066 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18381066 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:18381066 | pubmed:volume | 370 | lld:pubmed |
| pubmed-article:18381066 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18381066 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18381066 | pubmed:pagination | 248-53 | lld:pubmed |
| pubmed-article:18381066 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:18381066 | pubmed:meshHeading | pubmed-meshheading:18381066... | lld:pubmed |
| pubmed-article:18381066 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18381066 | pubmed:articleTitle | Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice. | lld:pubmed |
| pubmed-article:18381066 | pubmed:affiliation | Department of Physiology, The University of South Alabama College of Medicine, MSB 3074, 307 University Boulevard, Mobile, AL 36688-0002, USA. jyang@usouthal.edu | lld:pubmed |
| pubmed-article:18381066 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18381066 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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