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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-4-28
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pubmed:abstractText |
To assess the metabolic effects of chronic activation of AMP-activated protein kinase (AMPK) in liver, we generated a new transgenic (Tg) mouse model expressing constitutively active (CA)-AMPK-alpha1 in liver. In the short-term activation, the TgCA-AMPK-alpha1 mice exhibited minimal phenotype, but the Tg liver had elevated sterol regulatory element-binding protein (SREBP)-2 mRNA level and a parallel increase in transcripts of its target genes. UCP2 mRNA level was elevated. In the long-term activation, the TgCA-AMPK-alpha1 mice had markedly reduced white fat mass. The Tg liver had reduced mRNA expression of SREBP-1c and its target genes. Remarkably, the Tg mice were resistant to a high-fat diet-induced obesity. These data suggest that short-term chronic activation of AMPK-alpha1 in liver leads to compensatory increase in lipogenic gene expression due to increased SREBP-2 expression, and long-term chronic activation of AMPK-alpha1 decreases expression of SREBP-1c and its target genes, which results in reduced fat storage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1090-2104
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
370
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
248-53
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18381066-AMP-Activated Protein Kinases,
pubmed-meshheading:18381066-Adipose Tissue, White,
pubmed-meshheading:18381066-Adiposity,
pubmed-meshheading:18381066-Animals,
pubmed-meshheading:18381066-Dietary Fats,
pubmed-meshheading:18381066-Disease Models, Animal,
pubmed-meshheading:18381066-Enzyme Activation,
pubmed-meshheading:18381066-Gene Expression Regulation,
pubmed-meshheading:18381066-Lipogenesis,
pubmed-meshheading:18381066-Liver,
pubmed-meshheading:18381066-Mice,
pubmed-meshheading:18381066-Mice, Transgenic,
pubmed-meshheading:18381066-Multienzyme Complexes,
pubmed-meshheading:18381066-Obesity,
pubmed-meshheading:18381066-Phenotype,
pubmed-meshheading:18381066-Protein-Serine-Threonine Kinases,
pubmed-meshheading:18381066-Rats,
pubmed-meshheading:18381066-Sterol Regulatory Element Binding Protein 2
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pubmed:year |
2008
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pubmed:articleTitle |
Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice.
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pubmed:affiliation |
Department of Physiology, The University of South Alabama College of Medicine, MSB 3074, 307 University Boulevard, Mobile, AL 36688-0002, USA. jyang@usouthal.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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