Linked Life Data

18380407

Source:http://linkedlifedata.com/resource/pubmed/id/18380407

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2008-4-2
pubmed:abstractText
The new compound thienodiltiazem was synthesized and investigated regarding structure-activity relations and calcium antagonistic properties. Isometric contraction force was measured in guinea-pig papillary muscles and chronotropic activity was studied in right atria of guinea pigs. Compared to the parent drug diltiazem (CAS 42399-41-7) the thieno derivative had a more potent negative chronotropic effect on spontaneously beating right atria and a more potent inotropic effect on papillary muscles. The negative inotropic action was reversed by increasing the extracellular calcium concentration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
757-61
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Synthesis and biological activity of thienodiltiazem in isolated heart muscle preparations of guinea pigs.
pubmed:affiliation
Department of Pharmaceutical and Medicinal Chemistry, University of Vienna, Vienna, Austria.
pubmed:publicationType
Journal Article, In Vitro