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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-4-2
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pubmed:abstractText |
Treatment of patients with metastatic renal cell carcinoma is evolving rapidly due to the advent of novel targeted therapies. Improved knowledge of the underlying pathogenesis has led to the development of drugs that modulate the dominant signal transduction pathways for this disease, which results in inhibition of angiogenesis. Recent evidence indicates that the receptor tyrosine kinase inhibitor sunitinib prolongs progression-free survival compared with interferon-alpha, especially in patients with intermediate risk. Immunotherapy with interferon-alpha or high-dose interleukin-2 should still be considered for low-risk patients, particularly those with clear-cell tumours and metastases of the lung only. In patients who fail treatment with interferon-alpha, sorafenib has been shown to improve progression-free survival. High-risk patients may benefit from treatment with temsirolimus, which inhibits mammalian target of rapamycin (mTOR) kinase activity and has shown to improve overall survival. These angiogenesis inhibitors did not receive mention in the recently published guideline 'Renal cell carcinoma'.
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pubmed:commentsCorrections |
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pubmed:language |
dut
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzenesulfonates,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/bevacizumab,
http://linkedlifedata.com/resource/pubmed/chemical/sorafenib,
http://linkedlifedata.com/resource/pubmed/chemical/sunitinib,
http://linkedlifedata.com/resource/pubmed/chemical/temsirolimus
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0028-2162
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pubmed:author |
pubmed-author:GietemaJ AJA,
pubmed-author:GroenewegenGG,
pubmed-author:HaanenJ B A GJB,
pubmed-author:JansenR L HRL,
pubmed-author:KruitW H JWH,
pubmed-author:MuldersP F APF,
pubmed-author:OsantoSS,
pubmed-author:RichelD JDJ,
pubmed-author:SleijferSS,
pubmed-author:VoestE EEE,
pubmed-author:de MulderP H MPH,
pubmed-author:van den EertweghA J MAJ
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
152
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
371-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18380383-Angiogenesis Inhibitors,
pubmed-meshheading:18380383-Antibodies, Monoclonal,
pubmed-meshheading:18380383-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:18380383-Antineoplastic Agents,
pubmed-meshheading:18380383-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:18380383-Benzenesulfonates,
pubmed-meshheading:18380383-Carcinoma, Renal Cell,
pubmed-meshheading:18380383-Disease-Free Survival,
pubmed-meshheading:18380383-Humans,
pubmed-meshheading:18380383-Immunotherapy,
pubmed-meshheading:18380383-Indoles,
pubmed-meshheading:18380383-Kidney Neoplasms,
pubmed-meshheading:18380383-Neoplasm Metastasis,
pubmed-meshheading:18380383-Pyridines,
pubmed-meshheading:18380383-Pyrroles,
pubmed-meshheading:18380383-Signal Transduction,
pubmed-meshheading:18380383-Sirolimus,
pubmed-meshheading:18380383-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
[Angiogenesis inhibitors for the systemic treatment of metastatic renal cell carcinoma: sunitinib, sorafenib, bevacizumab and temsirolimus].
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pubmed:affiliation |
Universitair Medisch Centrum St Radboud, Nijmegen.
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pubmed:publicationType |
Journal Article,
Comment,
English Abstract,
Review
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