Linked Life Data

1838014

Source:http://linkedlifedata.com/resource/pubmed/id/1838014

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-3-10
pubmed:abstractText
Hepatocyte growth factor (HGF), a potent mitogen for mature hepatocytes in primary culture, was first found in sera of partial hepatectomized rats and seems to be a hepatotrophic factor for liver regeneration which has not been purified over the past 30 years. HGF is composed of the 69 kDa alpha-subunit and the 34 kDa beta-subunit. Molecular cloning reveals that HGF is derived from a single chain precursor of 728 amino acid residues and it contains 4 kringle domains in the alpha-subunit. HGF gene spans about 70kb and consists of 18 exons and 17 introns. HGF is now thought to be a pleiotropic factor influencing a cell growth and cell motility for various epithelial cells. HGF receptor with Kd = 20-30pm is widely distributed in various epithelial cells including hepatocytes. HGF mRNA and HGF activity increase markedly in liver after various liver injuries and in kidney following unilateral nephrectomy or acute renal injury. Moreover, HGF mRNA is induced even in the intact lung in response to liver and kidney injury. In situ hybridization reveals that HGF-producing cells are mesenchymal cells such as Kupffer cells and sinusoidal endothelial cells in liver, fenestrated endothelial cells in kidney, and macrophages and endothelial cells in lung. Thus, HGF may play an important role as a paracrine or endocrine mediator through an epithelial-mesenchymal interaction in wound-healing, tissue or organ regeneration, morphogenesis and carcinogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0955-2235
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-85
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Structure and function of hepatocyte growth factor.
pubmed:affiliation
Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't