Source:http://linkedlifedata.com/resource/pubmed/id/18379566
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2008-4-1
|
| pubmed:abstractText |
Peroxisome proliferator-activated receptor gamma (PPAR gamma) and peroxisome proliferator-activated receptor delta (PPAR delta) are promising candidate genes for obesity. Associations between adiposity-related phenotypes and genetic variation in PPAR gamma (Pro12Ala and C1431T), as well as PPAR delta (T+294C) were assessed in 2,102 Greek children aged 1-6 years, as part of a large-scale epidemiological study (Growth, Exercise and Nutrition Epidemiological Study In preSchoolers). In girls aged 3-4 years, the Ala12 allele was associated with higher mid-upper arm (P = 0.010) and hip (P = 0.005) circumferences, as well as subscapular (P = 0.008) and total skinfolds (P = 0.011) that explained 2.0, 3.7, 2.1, and 1.9% of the phenotypic variance, respectively, while the T1431 allele was associated with higher mean values for waist circumference (P = 0.018) and suprailiac skinfold (P = 0.017), genotype accounting for 1.6% of the variance in both phenotypes. No significant effects of PPAR delta T+294C polymorphism or the interaction of the PPAR delta and PPAR gamma variants on adiposity-related phenotypes were observed in any age group or gender. Haplotype-based analysis including both PPAR gamma polymorphisms revealed that in girls aged 3-4 years, the Ala-T haplotype was associated with higher waist (P = 0.014) and hip (P = 0.007) circumferences compared to the common Pro-C haplotype. The PPAR gamma Pro12Ala and C1431T polymorphisms are associated with increased adiposity during early childhood in a gender- and age-specific manner and independently of the PPAR delta T+294C polymorphism.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1930-7381
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| pubmed:author |
pubmed-author:ChenTun-Li JoshuaTL,
pubmed-author:GrammatikakiEvangeliaE,
pubmed-author:KortsalioudakiChristineC,
pubmed-author:LagouVasilikiV,
pubmed-author:LiarigkovinosThodorisT,
pubmed-author:ManiosYannisY,
pubmed-author:MoschonisGeorgeG,
pubmed-author:PitsiladisYannis PYP,
pubmed-author:Roma-GiannikouEleftheriaE,
pubmed-author:ScottRobert ARA,
pubmed-author:WangGuanG
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| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
913-8
|
| pubmed:meshHeading |
pubmed-meshheading:18379566-Adipose Tissue,
pubmed-meshheading:18379566-Age Distribution,
pubmed-meshheading:18379566-Child,
pubmed-meshheading:18379566-Child, Preschool,
pubmed-meshheading:18379566-Female,
pubmed-meshheading:18379566-Gene Frequency,
pubmed-meshheading:18379566-Genetic Predisposition to Disease,
pubmed-meshheading:18379566-Greece,
pubmed-meshheading:18379566-Haplotypes,
pubmed-meshheading:18379566-Humans,
pubmed-meshheading:18379566-Infant,
pubmed-meshheading:18379566-Male,
pubmed-meshheading:18379566-Obesity,
pubmed-meshheading:18379566-PPAR delta,
pubmed-meshheading:18379566-PPAR gamma,
pubmed-meshheading:18379566-Phenotype,
pubmed-meshheading:18379566-Polymorphism, Genetic,
pubmed-meshheading:18379566-Prevalence,
pubmed-meshheading:18379566-Sex Distribution
|
| pubmed:year |
2008
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| pubmed:articleTitle |
Impact of peroxisome proliferator-activated receptors gamma and delta on adiposity in toddlers and preschoolers in the GENESIS Study.
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| pubmed:affiliation |
Faculty of Biomedical and Life Sciences, Institute of Diet, Exercise and Lifestyle (IDEAL), University of Glasgow, Glasgow, UK.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|