| pubmed-article:18375498 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18375498 | lifeskim:mentions | umls-concept:C0007193 | lld:lifeskim |
| pubmed-article:18375498 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:18375498 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:18375498 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18375498 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:18375498 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18375498 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18375498 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18375498 | pubmed:dateCreated | 2008-7-30 | lld:pubmed |
| pubmed-article:18375498 | pubmed:abstractText | The molecular mechanisms that regulate cardiomyocyte apoptosis and their role in human heart failure (HF) are uncertain. Expression of the apoptosis regulator p53 is governed by minute double minute 2 (MDM2), an E3 enzyme that targets p53 for ubiquitination and proteasomal processing, and by the deubiquitinating enzyme, herpesvirus-associated ubiquitin-specific protease (HAUSP), which rescues p53 by removing ubiquitin chains from it. Here, we examined whether elevated expression of p53 was associated with dysregulation of ubiquitin-proteasome system (UPS) components and activation of downstream effectors of apoptosis in human dilated cardiomyopathy (DCM). | lld:pubmed |
| pubmed-article:18375498 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18375498 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375498 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18375498 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18375498 | pubmed:issn | 0008-6363 | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:HulsA HAH | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:YacoubMagdi... | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:Sarathchandra... | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:BartonPaul... | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:BirksEmma JEJ | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:LatifNajmaN | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:OvaaHuibH | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:EvansPaul CPC | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:EnesaKarineK | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:FolkvangTonje... | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:LuongLe... | lld:pubmed |
| pubmed-article:18375498 | pubmed:author | pubmed-author:TerraccianoCe... | lld:pubmed |
| pubmed-article:18375498 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18375498 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18375498 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:18375498 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18375498 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18375498 | pubmed:pagination | 472-80 | lld:pubmed |
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| pubmed-article:18375498 | pubmed:meshHeading | pubmed-meshheading:18375498... | lld:pubmed |
| pubmed-article:18375498 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18375498 | pubmed:articleTitle | Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy. | lld:pubmed |
| pubmed-article:18375498 | pubmed:affiliation | Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield Hospital, Harefield, UK. | lld:pubmed |
| pubmed-article:18375498 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18375498 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:7157 | entrezgene:pubmed | pubmed-article:18375498 | lld:entrezgene |
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