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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-7-30
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pubmed:abstractText |
The molecular mechanisms that regulate cardiomyocyte apoptosis and their role in human heart failure (HF) are uncertain. Expression of the apoptosis regulator p53 is governed by minute double minute 2 (MDM2), an E3 enzyme that targets p53 for ubiquitination and proteasomal processing, and by the deubiquitinating enzyme, herpesvirus-associated ubiquitin-specific protease (HAUSP), which rescues p53 by removing ubiquitin chains from it. Here, we examined whether elevated expression of p53 was associated with dysregulation of ubiquitin-proteasome system (UPS) components and activation of downstream effectors of apoptosis in human dilated cardiomyopathy (DCM).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/MDM2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PARP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-mdm2,
http://linkedlifedata.com/resource/pubmed/chemical/TP53 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/USP7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin Thiolesterase,
http://linkedlifedata.com/resource/pubmed/chemical/caspase-activated DNase inhibitor,
http://linkedlifedata.com/resource/pubmed/chemical/caspase-activated deoxyribonuclease
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0008-6363
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pubmed:author |
pubmed-author:BartonPaul J RPJ,
pubmed-author:BirksEmma JEJ,
pubmed-author:EnesaKarineK,
pubmed-author:EvansPaul CPC,
pubmed-author:FolkvangTonjeT,
pubmed-author:HulsA HAH,
pubmed-author:LatifNajmaN,
pubmed-author:LuongLe Anhle A,
pubmed-author:OvaaHuibH,
pubmed-author:SarathchandraPadminiP,
pubmed-author:TerraccianoCesare MCM,
pubmed-author:YacoubMagdi HMH
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
472-80
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pubmed:meshHeading |
pubmed-meshheading:18375498-Adult,
pubmed-meshheading:18375498-Apoptosis,
pubmed-meshheading:18375498-Apoptosis Regulatory Proteins,
pubmed-meshheading:18375498-Cardiomyopathy, Dilated,
pubmed-meshheading:18375498-Caspase 3,
pubmed-meshheading:18375498-Caspase 9,
pubmed-meshheading:18375498-DNA Fragmentation,
pubmed-meshheading:18375498-Deoxyribonucleases,
pubmed-meshheading:18375498-Female,
pubmed-meshheading:18375498-Humans,
pubmed-meshheading:18375498-Male,
pubmed-meshheading:18375498-Middle Aged,
pubmed-meshheading:18375498-Myocardium,
pubmed-meshheading:18375498-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:18375498-Proteasome Endopeptidase Complex,
pubmed-meshheading:18375498-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:18375498-Tumor Suppressor Protein p53,
pubmed-meshheading:18375498-Ubiquitin,
pubmed-meshheading:18375498-Ubiquitin Thiolesterase,
pubmed-meshheading:18375498-Up-Regulation,
pubmed-meshheading:18375498-Young Adult
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pubmed:year |
2008
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pubmed:articleTitle |
Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy.
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pubmed:affiliation |
Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield Hospital, Harefield, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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