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rdf:type |
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lifeskim:mentions |
umls-concept:C0003316,
umls-concept:C0009847,
umls-concept:C0021051,
umls-concept:C0024400,
umls-concept:C0026882,
umls-concept:C0039194,
umls-concept:C0042774,
umls-concept:C0085358,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C1880177,
umls-concept:C2698600
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pubmed:issue |
11
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pubmed:dateCreated |
2008-5-15
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pubmed:abstractText |
Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8(+) lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8(+) lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation of canonical epitopes. These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-10075982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-10227983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-10362819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-11014195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-11752176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-11797012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-12477431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-12805435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-12835706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-16128925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-16873273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-17202356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-8057491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-8207839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-9420212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-9565630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-9637523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18367519-9933172
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1098-5514
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pubmed:author |
pubmed-author:BaumeisterSusanne H CSH,
pubmed-author:FosterGabriel JGJ,
pubmed-author:KimEun-YoungEY,
pubmed-author:KurodaMarcelo JMJ,
pubmed-author:LetvinNorman LNL,
pubmed-author:LifsonJeffrey DJD,
pubmed-author:McEversKimberly JKJ,
pubmed-author:NewbergMichael HMH,
pubmed-author:PiatakMichaelMJr,
pubmed-author:RettMelisa DMD,
pubmed-author:RieberE PeterEP,
pubmed-author:SchmitzJörn EJE,
pubmed-author:VeazeyRonald SRS,
pubmed-author:WolinskySteven MSM,
pubmed-author:ZahnRolandR
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pubmed:issnType |
Electronic
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5631-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18367519-Animals,
pubmed-meshheading:18367519-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18367519-Epitopes, T-Lymphocyte,
pubmed-meshheading:18367519-Gene Products, gag,
pubmed-meshheading:18367519-Gene Products, tat,
pubmed-meshheading:18367519-Histocompatibility Antigens Class I,
pubmed-meshheading:18367519-Macaca mulatta,
pubmed-meshheading:18367519-Mutation,
pubmed-meshheading:18367519-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:18367519-Simian immunodeficiency virus,
pubmed-meshheading:18367519-Virus Replication
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pubmed:year |
2008
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pubmed:articleTitle |
Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys.
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pubmed:affiliation |
Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, 676 N. St. Clair St., Suite 200, Chicago, IL 60611, USA. e-kim@northwestern.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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