|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
24
|
|
pubmed:dateCreated |
1992-1-15
|
|
pubmed:abstractText |
Chromosomal region 11q23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from 11q23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;11), t(9;11), and t(11;19) translocations. The breakpoints cluster in a small DNA region of less than 5.8 kilobases.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0008-5472
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
51
|
|
pubmed:geneSymbol |
ALL-1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
|
|
pubmed:pagination |
6712-4
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1835902-Antigens, CD3,
pubmed-meshheading:1835902-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1835902-Blotting, Northern,
pubmed-meshheading:1835902-Blotting, Southern,
pubmed-meshheading:1835902-Chromosome Mapping,
pubmed-meshheading:1835902-Chromosomes, Human, Pair 11,
pubmed-meshheading:1835902-Chromosomes, Human, Pair 19,
pubmed-meshheading:1835902-Chromosomes, Human, Pair 4,
pubmed-meshheading:1835902-Chromosomes, Human, Pair 9,
pubmed-meshheading:1835902-Cloning, Molecular,
pubmed-meshheading:1835902-DNA, Neoplasm,
pubmed-meshheading:1835902-Humans,
pubmed-meshheading:1835902-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:1835902-RNA, Messenger,
pubmed-meshheading:1835902-RNA, Neoplasm,
pubmed-meshheading:1835902-Receptors, Antigen, T-Cell,
pubmed-meshheading:1835902-Restriction Mapping,
pubmed-meshheading:1835902-Translocation, Genetic
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations.
|
|
pubmed:affiliation |
Jefferson Cancer Institute, Jefferson Cancer Center, Philadelphia, Pennsylvania.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
