Linked Life Data

18357780

Source:http://linkedlifedata.com/resource/pubmed/id/18357780

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-3-24
pubmed:abstractText
Data are presented concerning the basic metabolism sites, the reaction paths crossing in them and regulatory and toxical effect of formaldehyde and nitric oxide being mediated through them. In particular, they include: glutathione-formaldehyde-dependent dehydrogenase path of S-nitrosoglutathione reduction, semi-carbaside-sensitive amino-oxidase (SSAO) and NO-synthase systems; transformation of thioproline and metallothioneines, including nitrosation reactions. Possibilities of hexamethylenetetramine synthesis in the organism as well as its metabolism in conditions of formaldehyde hyperproduction and nitrosative stress are discussed. The role of metabolism sites, common for formaldehyde and nitrogen oxide, in the mechanisms of toxical effect of these compounds and development of pathologic states is considered.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0201-8470
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
72-90
pubmed:meshHeading
pubmed:articleTitle
[Role of interaction of metabolism pathways of formaldehyde and nitric oxide in the mechanism of their toxic effect. 3. Main metabolism sites of formaldehyde and nitric oxide mediating their effect].
pubmed:publicationType
Journal Article, English Abstract, Review