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rdf:type |
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lifeskim:mentions |
umls-concept:C0006272,
umls-concept:C0039082,
umls-concept:C0084692,
umls-concept:C0220901,
umls-concept:C0229671,
umls-concept:C0332152,
umls-concept:C0332835,
umls-concept:C0441889,
umls-concept:C1504431,
umls-concept:C1522609,
umls-concept:C1527148,
umls-concept:C1554112,
umls-concept:C1705576
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pubmed:issue |
1
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pubmed:dateCreated |
2008-7-9
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pubmed:abstractText |
Bronchiolitis obliterans syndrome (BOS) and idiopathic pneumonia syndrome (IPS) cause high mortality and impaired survival after allogeneic hematopoietic stem-cell transplantation (allo-HSCT). Early recognition of patients at high risk of developing BOS/IPS may lead to improving the outcome of allo-HSCT. We retrospectively analyzed serum surfactant protein A, D (SP-A, -D) and Kerbs von Lungren 6 Ag (KL-6) levels before allo-HSCT in 56 patients who survived more than 90 days after allo-HSCT and compared values of these serum markers and other transplant factors in BOS/IPS patients with those in non-BOS/IPS patients. Five patients developed BOS and two developed IPS at a median interval of 303 and 117 days (range, 100-452 and 95-153) from transplantation. As a result of univariate analysis, pretransplant serum SP-D levels but not SP-A, KL-6 in BOS/IPS patients were significantly lower than those in non-BOS/IPS patients (P=0.03). In multivariate analysis, the patients with lower pretransplant serum SP-D level had a trend toward frequent development of BOS/IPS (P=0.08). Constitutive serum SP-D level before allo-HSCT may be a useful, noninvasive predictor for the development of BOS/IPS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0268-3369
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pubmed:author |
pubmed-author:KAYJ MJM,
pubmed-author:KOUSJ CJC,
pubmed-author:KamoiHH,
pubmed-author:KanashimaHH,
pubmed-author:KohHH,
pubmed-author:NakamaeHH,
pubmed-author:NakamaeMM,
pubmed-author:NakaneTT,
pubmed-author:OhtaKK,
pubmed-author:SakamotoEE,
pubmed-author:TakeokaYY,
pubmed-author:TeradaYY,
pubmed-author:YamaneTT
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
43-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18347569-Adolescent,
pubmed-meshheading:18347569-Adult,
pubmed-meshheading:18347569-Aged,
pubmed-meshheading:18347569-Biological Markers,
pubmed-meshheading:18347569-Bronchiolitis Obliterans,
pubmed-meshheading:18347569-Cohort Studies,
pubmed-meshheading:18347569-Female,
pubmed-meshheading:18347569-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:18347569-Humans,
pubmed-meshheading:18347569-Male,
pubmed-meshheading:18347569-Middle Aged,
pubmed-meshheading:18347569-Mucin-1,
pubmed-meshheading:18347569-Pneumonia,
pubmed-meshheading:18347569-Prognosis,
pubmed-meshheading:18347569-Pulmonary Surfactant-Associated Protein A,
pubmed-meshheading:18347569-Pulmonary Surfactant-Associated Protein D,
pubmed-meshheading:18347569-Retrospective Studies,
pubmed-meshheading:18347569-Syndrome,
pubmed-meshheading:18347569-Transplantation, Homologous
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pubmed:year |
2008
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pubmed:articleTitle |
Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation.
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pubmed:affiliation |
Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University, Abeno-ku, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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