|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
1991-12-16
|
|
pubmed:abstractText |
Helper T lymphocytes provide a contact dependent signal to resting B cells that is required for optimal differentiation into Ig-secreting cells. The surface structure(s) on T cells that mediate helper function have not been identified but are known to be induced by T cell activation. A CD4- subclone of the Jurkat leukemic T cell line (D1.1) was isolated and found to be distinct from CD4+ Jurkat clones and a variety of other T and non-T cell leukemic lines in that coculture of D1.1 with resting B cells induced B cells to specifically express surface CD23 molecules, a marker of B cell activation. Furthermore, Jurkat D1.1 induced B cell proliferation and terminal B cell differentiation into IgG-secreting cells in the presence of T cell-dependent B cell mitogens. Similar to the helper effector function of activated T cells, the effects of Jurkat D1.1 were neither Ag nor MHC restricted. Paraformaldehyde fixed Jurkat D1.1 cells remained competent to activate B cells while D1.1 supernatants and diffusible factors were inactive. The effect of Jurkat D1.1 on B cell activation was distinct from that of rIL-4 and was not inhibited by antibodies to IL-4. Together these observations suggested that surface structures on D1.1 and not secreted factors, mediated contact-dependent helper effector function.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Mitomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fc,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
147
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3389-95
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:1834738-Antigens, CD,
pubmed-meshheading:1834738-Antigens, CD4,
pubmed-meshheading:1834738-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:1834738-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1834738-B-Lymphocytes,
pubmed-meshheading:1834738-Clone Cells,
pubmed-meshheading:1834738-Flow Cytometry,
pubmed-meshheading:1834738-Humans,
pubmed-meshheading:1834738-Interleukin-4,
pubmed-meshheading:1834738-Leukemia, T-Cell,
pubmed-meshheading:1834738-Lymphocyte Activation,
pubmed-meshheading:1834738-Lymphocyte Cooperation,
pubmed-meshheading:1834738-Mitomycin,
pubmed-meshheading:1834738-Receptors, Antigen, B-Cell,
pubmed-meshheading:1834738-Receptors, Fc,
pubmed-meshheading:1834738-Receptors, IgE,
pubmed-meshheading:1834738-T-Lymphocyte Subsets,
pubmed-meshheading:1834738-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:1834738-Tumor Cells, Cultured
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
A human CD4- T cell leukemia subclone with contact-dependent helper function.
|
|
pubmed:affiliation |
Department of Medicine, Columbia University, New York, NY 10032.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
