Source:http://linkedlifedata.com/resource/pubmed/id/18344842
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2008-7-3
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pubmed:abstractText |
High-mobility group box (HMGB) 1 is a recently discovered proinflammatory mediator that contributes to acute lung injury. We determined HMGB-1 levels in bronchoalveolar lavage fluid of patients during mechanical ventilation (MV) and ventilator-associated pneumonia (VAP). Bronchoalveolar lavage fluid was obtained from patients who were ventilated for 5 h because of an elective surgical procedure ("short-term MV"; n = 40) or for several days because of respiratory failure without acute lung injury ("long-term MV"; n = 10) and from patients who developed unilateral VAP (n = 4). Ten healthy volunteers served as controls. In healthy volunteers, HMGB-1 levels were low (median, 1.6 ngmL(-1); interquartile range [IQR], 0.7-3.7 ng mL(-1)). Although HMGB-1 levels were elevated after short-term MV, differences were not statistically significant compared with healthy volunteers (1.7 ng mL(-1); IQR, 0.8-8.5 ng mL(-1), P = 0.493 vs. healthy volunteers; P = 0.250 vs. start of MV). However, HMGB-1 levels were significantly higher in "long-term" MV patients (11.7 ng mL(-1); IQR, 8.7-37.0 ng mL(-1); P < 0.0001 vs. healthy volunteers). With unilateral VAP, HMGB-1 levels from the infected lung.were 17.4 (IQR, 8.5-23.2) ng mL(-1) (P = 0.014 vs. healthy controls); these levels were not different from those measured in the contralateral noninfected lung (P = 0.625). Summarized, long-term MV is associated with increased HMGB-1 levels in contrast to "short-term" MV. In addition, HMGB-1 levels during VAP are increased compared with healthy volunteers; however, they are not different from those found in patients intubated and mechanically ventilated for a similar period of time.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1073-2322
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
441-5
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pubmed:meshHeading |
pubmed-meshheading:18344842-Adult,
pubmed-meshheading:18344842-Aged,
pubmed-meshheading:18344842-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:18344842-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18344842-Female,
pubmed-meshheading:18344842-HMGB1 Protein,
pubmed-meshheading:18344842-Humans,
pubmed-meshheading:18344842-Lung,
pubmed-meshheading:18344842-Male,
pubmed-meshheading:18344842-Middle Aged,
pubmed-meshheading:18344842-Pneumonia, Ventilator-Associated,
pubmed-meshheading:18344842-Respiration, Artificial,
pubmed-meshheading:18344842-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Pulmonary levels of high-mobility group box 1 during mechanical ventilation and ventilator-associated pneumonia.
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pubmed:affiliation |
Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands. M.A.vanZoelen@amc.uva.nl
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
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