Linked Life Data

18342513

Source:http://linkedlifedata.com/resource/pubmed/id/18342513

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-5-5
pubmed:abstractText
Early diagnosis of ventriculostomy-associated cerebrospinal fluid (CSF) infection in acute neurosurgical patients can be difficult. The use of prophylactic antibiotics in intraventricular or subarachnoid haemorrhage decreases the sensitivity of cell counts, Gram staining and bacterial culture as diagnostic tools. We prospectively collected clinical and cerebrospinal data for 16 patients with intraventricular haemorrhage, with an external ventricular drain inserted, with or without spontaneous subarachnoid haemorrhage. Three (18.8%) patients had cerebrospinal fluid infection, with appropriate changes in antibiotic regimens needed. All three patients had CSF lactate levels of >4 mmol/L (6.4 mmol/L, 7.8 mmol/L, 7.9 mmol/L). Eleven out of 13 patients without CSF infection had CSF lactate levels of below 4 mmol/L. The two patients with CSF lactate levels of 4-6 mmol/L were grade 5 subarachnoid haemorrhage patients, one with renal impairment. Using a cut-off lactate level of 4 mmol/L, the positive predictive value was 60% and negative predictive value was 100% for CSF infection. A CSF lactate level of above 4 mmol/L should prompt suspicion of CSF infection in intraventricular haemorrhage patients with an external ventricular drain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0967-5868
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
654-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Use of ventricular cerebrospinal fluid lactate measurement to diagnose cerebrospinal fluid infection in patients with intraventricular haemorrhage.
pubmed:affiliation
Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR. georgewong@surgery.cuhk.edu.hk
pubmed:publicationType
Journal Article