Source:http://linkedlifedata.com/resource/pubmed/id/18339522
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-6-16
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| pubmed:abstractText |
The prevalence and molecular epidemiology of pneumococcal macrolide resistance in South Africa was investigated. Minimum inhibitory concentrations and serotypes of pneumococcal isolates causing invasive disease from 2000-2005 (n=15982), collected through a national laboratory-based surveillance system, were determined. Randomly selected isolates from 2005 (51%; 260/508) had resistance mechanisms determined, and clonality was investigated by pulsed-field gel electrophoresis (PFGE) (n=64) and multilocus sequence typing (n=7). Macrolide resistance increased from 9% (160/1828) in 2000 to 14% (508/3656) in 2005 (P<0.001). Serotype 14 was the most common macrolide-resistant serotype (40%; 760/1921). The majority of macrolide-resistant isolates (75%; 1437/1921) displayed the macrolide-lincosamide-streptogramin B (MLS(B)) phenotype. Of the strains screened genotypically, 57% (147/260) contained erm(B), 27% (71/260) contained mef(A) and 15% (40/260) contained erm(B) and mef(A); 1% (2/260) contained ribosomal mutations. Macrolide-resistant isolates were predominantly penicillin-non-susceptible and multidrug-resistant. Isolates clustered according to serotype by PFGE, and 22% (14/64), 11% (7/64) and 5% (3/64) of isolates were related to the Taiwan(19F)-14, England(14)-9 and Spain(9V)-3 global clones, respectively. Routine use of the 7-valent pneumococcal conjugate vaccine (PCV-7) could reduce the burden of macrolide-resistant pneumococcal disease in South Africa.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0924-8579
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
32
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
62-7
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:18339522-Adolescent,
pubmed-meshheading:18339522-Anti-Bacterial Agents,
pubmed-meshheading:18339522-Bacterial Typing Techniques,
pubmed-meshheading:18339522-Child,
pubmed-meshheading:18339522-Child, Preschool,
pubmed-meshheading:18339522-Cluster Analysis,
pubmed-meshheading:18339522-DNA, Bacterial,
pubmed-meshheading:18339522-DNA Fingerprinting,
pubmed-meshheading:18339522-Drug Resistance, Bacterial,
pubmed-meshheading:18339522-Drug Resistance, Multiple, Bacterial,
pubmed-meshheading:18339522-Electrophoresis, Gel, Pulsed-Field,
pubmed-meshheading:18339522-Genotype,
pubmed-meshheading:18339522-Humans,
pubmed-meshheading:18339522-Infant,
pubmed-meshheading:18339522-Infant, Newborn,
pubmed-meshheading:18339522-Macrolides,
pubmed-meshheading:18339522-Microbial Sensitivity Tests,
pubmed-meshheading:18339522-Molecular Epidemiology,
pubmed-meshheading:18339522-Pneumococcal Infections,
pubmed-meshheading:18339522-Serotyping,
pubmed-meshheading:18339522-South Africa,
pubmed-meshheading:18339522-Streptococcus pneumoniae
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| pubmed:year |
2008
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| pubmed:articleTitle |
Molecular basis and clonal nature of increasing pneumococcal macrolide resistance in South Africa, 2000-2005.
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| pubmed:affiliation |
Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council and University of the Witwatersrand, Sandringham, South Africa. nicolew@nicd.ac.za
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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