|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2008-3-12
|
|
pubmed:abstractText |
SOX9 is a transcription factor that fulfills multiple functions during development. In the hair follicle SOX9 is expressed in the outer layer of the epithelial sheath, and the hair stem cell compartment. Recent data suggest that Sox9 acts as a downstream target of the Sonic hedgehog (Shh) pathway. Activation of the Shh pathway is a major cause of cutaneous basal cell carcinoma (BCC). Here we test whether activation of SOX9 is a general feature of BCC, or whether it could be used as a biomarker to better define subtypes of these skin tumors. In addition we investigated SOX9 expression in other skin epidermal tumors.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1600-0560
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
35
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
373-9
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:18333897-Carcinoma, Basal Cell,
pubmed-meshheading:18333897-Diagnosis, Differential,
pubmed-meshheading:18333897-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:18333897-High Mobility Group Proteins,
pubmed-meshheading:18333897-Humans,
pubmed-meshheading:18333897-Microscopy, Fluorescence,
pubmed-meshheading:18333897-Neoplasms, Adnexal and Skin Appendage,
pubmed-meshheading:18333897-SOX9 Transcription Factor,
pubmed-meshheading:18333897-Skin Neoplasms,
pubmed-meshheading:18333897-Transcription Factors,
pubmed-meshheading:18333897-Tumor Markers, Biological
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms.
|
|
pubmed:affiliation |
INSERM, U636, Nice, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
