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rdf:type |
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lifeskim:mentions |
umls-concept:C0018330,
umls-concept:C0018338,
umls-concept:C0078058,
umls-concept:C0086418,
umls-concept:C0181586,
umls-concept:C0220781,
umls-concept:C0227813,
umls-concept:C0439596,
umls-concept:C1135918,
umls-concept:C1157570,
umls-concept:C1171892,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1883254
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pubmed:issue |
7
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pubmed:dateCreated |
2008-7-22
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pubmed:abstractText |
Vascular smooth muscle cells express endothelial nitric oxide synthase (eNOS) and produce nitric oxide (NO). Recently, increased NO production has been reported to induce the synthesis and secretion of vascular endothelial growth factor (VEGF) via the NO/cyclic guanosine 3',5'-monophosphate (cGMP) pathway. L-arginine (L-arg), the precursor of NO, and selective phosphodiesterase type 5 (PDE-5) inhibitors that increase levels of intracellular cGMP may complementarily enhance VEGF synthesis in corpus cavernosal smooth muscle cells (CCSMCs), and may consequently restore impaired endothelial function. Expression of eNOS in corpus cavernosal smooth muscle has also been reported. However, it is unclear whether CCSMCs can generate NO.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/Triazines,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/vardenafil
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1743-6109
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1623-35
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pubmed:meshHeading |
pubmed-meshheading:18331270-Arginine,
pubmed-meshheading:18331270-Cyclic GMP,
pubmed-meshheading:18331270-Humans,
pubmed-meshheading:18331270-Imidazoles,
pubmed-meshheading:18331270-Male,
pubmed-meshheading:18331270-Middle Aged,
pubmed-meshheading:18331270-Muscle, Smooth, Vascular,
pubmed-meshheading:18331270-Myocytes, Smooth Muscle,
pubmed-meshheading:18331270-Nitric Oxide,
pubmed-meshheading:18331270-Nitric Oxide Synthase Type III,
pubmed-meshheading:18331270-Penis,
pubmed-meshheading:18331270-Phosphodiesterase Inhibitors,
pubmed-meshheading:18331270-Piperazines,
pubmed-meshheading:18331270-Signal Transduction,
pubmed-meshheading:18331270-Sulfones,
pubmed-meshheading:18331270-Triazines,
pubmed-meshheading:18331270-Vascular Endothelial Growth Factor A,
pubmed-meshheading:18331270-Vasodilator Agents
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pubmed:year |
2008
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pubmed:articleTitle |
Nitric oxide synthesis leads to vascular endothelial growth factor synthesis via the NO/cyclic guanosine 3',5'-monophosphate (cGMP) pathway in human corpus cavernosal smooth muscle cells.
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pubmed:affiliation |
Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
Case Reports
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