Linked Life Data

1832881

Source:http://linkedlifedata.com/resource/pubmed/id/1832881

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-11-6
pubmed:abstractText
Since the genes for two of the T cell receptor (TCR) chains (alpha and delta) and for the immunoglobulin (Ig) heavy chains (alpha, gamma, delta, epsilon and mu) are all on the long arm of human chromosome 14, it is of interest to determine if they are genetically linked and, if so, how strongly. We tested genetic polymorphisms of the TCR alpha-locus and Ig gamma-locus in 19 families comprising 107 members, and asssessed the frequency of recombination between the two loci. The results rule out strong linkage: all recombination fractions below 0.26 gave lod scores less than -2 (odds less than 1:100). Combining the data on maternal and paternal meioses, the most likely recombination fraction was 0.5 (nonlinkage).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0254-9670
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-10
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Human genes for the immunoglobulin gamma-chain (Gm) allotypes and for the T cell receptor alpha-chain are distantly linked or unlinked.
pubmed:affiliation
American Red Cross Blood Services, Madison, Wisc.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't