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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-31
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pubmed:abstractText |
Herpes simplex virus (HSV) infection of the cornea culminates in an immunopathological lesion (stromal keratitis--SK) that impairs vision. This report shows that HSV infection results in IL-23 up-regulation, but if this response fails to occur, as was noted in p19-/- mice, the severity of lesions, their incidence and the level of viral induced angiogenesis were significantly increased compared to wild-type (WT) animals (p<0.05). The higher disease severity in p19-/- mice appeared to be the consequence of an increased IL-12 response that in turn led to the induction of higher numbers of IFN-gamma producing CD4(+)T cells, the principal orchestrators of SK. Our results indicate that the severity of HSV induced immunopathological lesions may be mainly the consequence of IL-12 driven Th1 T cell reactions rather than the action of IL-17 producing cells controlled by IL-23.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-10333107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-10433361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-10556823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-11559816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-11867592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-11888686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-12223525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-12417590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-12421973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-12457985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-12610626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-14662908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-15507126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-15516327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-15657292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-15731058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-16157683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-16342235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-16648837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-16670765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-16920909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-16979664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-17085599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-17137775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-17266445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-17442974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-7935054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-8523513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-9781806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18325811-9989981
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1286-4579
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
302-12
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:18325811-Animals,
pubmed-meshheading:18325811-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18325811-Cell Division,
pubmed-meshheading:18325811-Cornea,
pubmed-meshheading:18325811-Female,
pubmed-meshheading:18325811-Herpes Simplex,
pubmed-meshheading:18325811-Herpesvirus 1, Human,
pubmed-meshheading:18325811-Inflammation,
pubmed-meshheading:18325811-Interferon-gamma,
pubmed-meshheading:18325811-Interleukin-12,
pubmed-meshheading:18325811-Interleukin-23,
pubmed-meshheading:18325811-Keratitis, Herpetic,
pubmed-meshheading:18325811-Lymph Nodes,
pubmed-meshheading:18325811-Mice,
pubmed-meshheading:18325811-Mice, Inbred BALB C,
pubmed-meshheading:18325811-Mice, Knockout,
pubmed-meshheading:18325811-Molecular Weight,
pubmed-meshheading:18325811-Protein Subunits,
pubmed-meshheading:18325811-Spleen,
pubmed-meshheading:18325811-Virulence,
pubmed-meshheading:18325811-Virus Replication
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pubmed:year |
2008
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pubmed:articleTitle |
Enhanced viral immunoinflammatory lesions in mice lacking IL-23 responses.
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pubmed:affiliation |
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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