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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-4
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pubmed:abstractText |
Although anxiety disorders are heritable, their genetic and phenotypic complexity has made the identification of susceptibility genes difficult. Well-validated animal models and intermediate phenotypes provide crucial tools for genetic dissection of anxiety. The gene encoding regulator of G protein signaling 2 (Rgs2) is a quantitative trait gene that influences mouse anxiety behavior, making its human ortholog (RGS2) a compelling candidate gene for human anxiety phenotypes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1538-3636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
298-308
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pubmed:meshHeading |
pubmed-meshheading:18316676-Adult,
pubmed-meshheading:18316676-Anxiety Disorders,
pubmed-meshheading:18316676-Brain,
pubmed-meshheading:18316676-Case-Control Studies,
pubmed-meshheading:18316676-Child,
pubmed-meshheading:18316676-Child, Preschool,
pubmed-meshheading:18316676-Emotions,
pubmed-meshheading:18316676-Female,
pubmed-meshheading:18316676-Genetic Predisposition to Disease,
pubmed-meshheading:18316676-Humans,
pubmed-meshheading:18316676-Infant,
pubmed-meshheading:18316676-Magnetic Resonance Imaging,
pubmed-meshheading:18316676-Male,
pubmed-meshheading:18316676-Mental Processes,
pubmed-meshheading:18316676-Personality,
pubmed-meshheading:18316676-Phenotype,
pubmed-meshheading:18316676-Polymorphism, Single Nucleotide,
pubmed-meshheading:18316676-RGS Proteins,
pubmed-meshheading:18316676-Temperament
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pubmed:year |
2008
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pubmed:articleTitle |
Influence of RGS2 on anxiety-related temperament, personality, and brain function.
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pubmed:affiliation |
Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. jsmoller@hms.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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