Linked Life Data

18314742

Source:http://linkedlifedata.com/resource/pubmed/id/18314742

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-3-4
pubmed:abstractText
Mitochondria are key players in cell death following intrinsic and, in some cell types, extrinsic stimuli. The recruitment of the mitochondrial pathway results in mitochondrial dysfunction and release of intermembrane space proteins like cytochrome-c that are required in the cytosol for complete activation of effector caspases. Apoptotic shape changes of this organelle and the role of "mitochondria-shaping" proteins in cell death has attracted considerable attention. We present protocols to investigate how morphological changes of the mitochondrial reticulum regulate release of cytochrome-c, as evaluated quantitatively by an in situ approach, and changes in mitochondrial membrane potential measured in real time.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1064-3745
pubmed:author
pubmed:issnType
Print
pubmed:volume
372
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-20
pubmed:dateRevised
2009-4-6
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Measuring mitochondrial shape changes and their consequences on mitochondrial involvement during apoptosis.
pubmed:affiliation
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Padova, Italy.
pubmed:publicationType
Journal Article