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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-3-28
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pubmed:abstractText |
alpha-Fetoprotein (AFP) is frequently detected in hepatocellular carcinomas (HCCs) and AT motif binding factor 1 (ATBF1) down-regulates AFP gene expression in hepatic cells. The ATBF1 gene also inhibits cell growth and differentiation, and altered gene expression is associated with malignant transformation. The aim was to investigate the potential role of the ATBF1 gene in HCCs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1365-2559
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
552-9
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pubmed:dateRevised |
2008-9-13
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pubmed:meshHeading |
pubmed-meshheading:18312352-Adult,
pubmed-meshheading:18312352-Aged,
pubmed-meshheading:18312352-Aged, 80 and over,
pubmed-meshheading:18312352-Carcinoma, Hepatocellular,
pubmed-meshheading:18312352-DNA, Neoplasm,
pubmed-meshheading:18312352-DNA Methylation,
pubmed-meshheading:18312352-DNA Mutational Analysis,
pubmed-meshheading:18312352-Disease Progression,
pubmed-meshheading:18312352-Down-Regulation,
pubmed-meshheading:18312352-Female,
pubmed-meshheading:18312352-Gene Silencing,
pubmed-meshheading:18312352-Homeodomain Proteins,
pubmed-meshheading:18312352-Humans,
pubmed-meshheading:18312352-Liver Neoplasms,
pubmed-meshheading:18312352-Loss of Heterozygosity,
pubmed-meshheading:18312352-Male,
pubmed-meshheading:18312352-Middle Aged,
pubmed-meshheading:18312352-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:18312352-RNA, Messenger,
pubmed-meshheading:18312352-RNA, Neoplasm
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pubmed:year |
2008
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pubmed:articleTitle |
Down-regulation of ATBF1 is a major inactivating mechanism in hepatocellular carcinoma.
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pubmed:affiliation |
Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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