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rdf:type |
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lifeskim:mentions |
umls-concept:C0006622,
umls-concept:C0009209,
umls-concept:C0017262,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0026844,
umls-concept:C0185117,
umls-concept:C0439851,
umls-concept:C0441655,
umls-concept:C0752313,
umls-concept:C1135918,
umls-concept:C1417203,
umls-concept:C1449695,
umls-concept:C1552596,
umls-concept:C1618608,
umls-concept:C1824520,
umls-concept:C1879547,
umls-concept:C1947931,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2008-6-16
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pubmed:abstractText |
Expression and activation of matrix metalloproteinase (MMP)-2 play pivotal roles in the migration and invasion of human aortic vascular smooth muscle cells (VSMC) originating from normal human tissue, which is strongly linked to atherosclerosis. The present study investigated the possible inhibitory effects of cocoa procyanidin on thrombin-induced expression and activation of MMP-2 in VSMC.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biflavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Catechin,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 14,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Preparations,
http://linkedlifedata.com/resource/pubmed/chemical/Proanthocyanidins,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/procyanidin B2
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-41
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18310679-Aorta,
pubmed-meshheading:18310679-Biflavonoids,
pubmed-meshheading:18310679-Cacao,
pubmed-meshheading:18310679-Catechin,
pubmed-meshheading:18310679-Cell Movement,
pubmed-meshheading:18310679-Cells, Cultured,
pubmed-meshheading:18310679-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:18310679-Humans,
pubmed-meshheading:18310679-MAP Kinase Kinase 1,
pubmed-meshheading:18310679-Matrix Metalloproteinase 14,
pubmed-meshheading:18310679-Matrix Metalloproteinase 2,
pubmed-meshheading:18310679-Muscle, Smooth, Vascular,
pubmed-meshheading:18310679-Plant Preparations,
pubmed-meshheading:18310679-Proanthocyanidins,
pubmed-meshheading:18310679-Thrombin
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pubmed:year |
2008
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pubmed:articleTitle |
Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities.
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pubmed:affiliation |
Department of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University, Seoul 151-921, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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