Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2008-3-5
pubmed:abstractText
Cancers arise by the gradual accumulation of mutations in multiple genes. We now use shotgun pyrosequencing to characterize RNA mutations and expression levels unique to malignant pleural mesotheliomas (MPMs) and not present in control tissues. On average, 266 Mb of cDNA were sequenced from each of four MPMs, from a control pulmonary adenocarcinoma (ADCA), and from normal lung tissue. Previously observed differences in MPM RNA expression levels were confirmed. Point mutations were identified by using criteria that require the presence of the mutation in at least four reads and in both cDNA strands and the absence of the mutation from sequence databases, normal adjacent tissues, and other controls. In the four MPMs, 15 nonsynonymous mutations were discovered: 7 were point mutations, 3 were deletions, 4 were exclusively expressed as a consequence of imputed epigenetic silencing, and 1 was putatively expressed as a consequence of RNA editing. Notably, each MPM had a different mutation profile, and no mutated gene was previously implicated in MPM. Of the seven point mutations, three were observed in at least one tumor from 49 other MPM patients. The mutations were in genes that could be causally related to cancer and included XRCC6, PDZK1IP1, ACTR1A, and AVEN.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-10225435, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-10496535, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-10862040, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-10949025, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-11375892, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-11493912, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-12082024, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-12101425, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-12168054, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-12208747, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-12631724, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-15004035, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-15122206, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-15389593, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-15879497, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-15920167, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-15998913, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-16056220, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-16100382, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-16216411, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-16675105, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-16775426, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-16798876, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-16869737, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-16883574, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-16959974, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-16965949, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-16969506, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-17108958, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-17122850, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-17234753, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-17253596, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-17253597, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-17289874, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-17320506, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-17344839, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-17344846, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-17982442, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-8541092, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-8701988, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-9815914, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303113-9927061
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/ACVR1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/AVEN protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Activin Receptors, Type I, http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Nuclear, http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Ku autoantigen, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PDZK1IP1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
4
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3521-6
pubmed:dateRevised
2010-9-22
pubmed:meshHeading
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