Linked Life Data

18302031

Source:http://linkedlifedata.com/resource/pubmed/id/18302031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-2-27
pubmed:abstractText
pH-sensitive vesicles are designed to promote efficient release of entrapped agents in response to low pH. In this study, such vesicles were prepared from cholesteryl hemisuccinate (CHEMS) in Tris-HCl buffer. Vesicles prepared by this direct hydration method had a small particle size of 74.1 nm based on intensity of Gaussian and a size of 65.8 nm based on volume of Gaussian. The mean zeta potential was about -73mV, indicating that the vesicle system was stable. Entrapment efficiency for calcein by these vesicles was measured at 37 +/- 2.36%, which is higher than that by phospholipid MLVs. These calcein loaded vesicles exhibited excellent stability at pH 7.4 and underwent rapid destabilization upon acidification as showed by calcein release. However these vesicles were unstable in Fetal Bovine Serum (FBS). Optimization of formulation might improve their stability in serum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0363-9045
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
134-41
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Preparation and characterization of pH-sensitive vesicles made of cholesteryl hemisuccinate.
pubmed:affiliation
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, PR, China.
pubmed:publicationType
Journal Article