Linked Life Data

18295576

Source:http://linkedlifedata.com/resource/pubmed/id/18295576

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-2-25
pubmed:abstractText
Reprogramming of somatic cells to a pluripotent embryonic stem cell-like state has been achieved by nuclear transplantation of a somatic nucleus into an enucleated egg and most recently by introducing defined transcription factors into somatic cells. Nuclear reprogramming is of great medical interest, as it has the potential to generate a source of patient-specific cells. Here, we review strategies to reprogram somatic cells to a pluripotent embryonic state and discuss our understanding of the molecular mechanisms of reprogramming based on recent insights into the regulatory circuitry of the pluripotent state.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1097-4172
pubmed:author
pubmed:issnType
Electronic
pubmed:day
22
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
567-82
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming.
pubmed:affiliation
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. jaenisch@wi.mit.edu
pubmed:publicationType
Journal Article, Review