18291340

Source:http://linkedlifedata.com/resource/pubmed/id/18291340

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0023281, umls-concept:C0029216, umls-concept:C0376387, umls-concept:C0524930
pubmed:issue	3
pubmed:dateCreated	2008-2-22
pubmed:abstractText	Leishmaniasis is a rarely reported disease among transplant recipients; however, the number of published cases has quadrupled since the beginning of the 1990s. Most cases have been observed in patients living in countries of the Mediterranean basin. Leishmaniasis is most commonly associated with kidney transplantation (77%), and cases are also recorded among patients undergoing liver, heart, lung, pancreas, and bone marrow transplantation. Visceral leishmaniasis (VL) is the most frequently observed clinical presentation, followed by mucosal leishmaniasis and more rarely cutaneous leishmaniasis. Transplant recipients with VL develop the classic clinical form of the disease, which is a febrile hepatosplenic and pancytopenic syndrome. Immunodepression seems to predispose to development of mucosal leishmaniasis caused by viscerotropic strains. Early diagnosis of VL is crucial for patient therapy and outcome; however, this is frequently overlooked or delayed in transplant patients. Pentavalent antimonials are the most commom form of treatment for VL, but have a high incidence of toxicity (34%). Although used in fewer patients, liposomal amphotericin B seems to be better tolerated and should be considered as first-line therapy in transplant recipients.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101130150
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1473-3099
pubmed:author	pubmed-author:AntinoriSpinelloS, pubmed-author:BianchiRobertoR, pubmed-author:CascioAntonioA, pubmed-author:CorbellinoMarioM, pubmed-author:ParraviciniCarloC
pubmed:issnType	Print
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	191-9
pubmed:meshHeading	pubmed-meshheading:18291340-Humans, pubmed-meshheading:18291340-Leishmaniasis, Visceral, pubmed-meshheading:18291340-Mediterranean Region, pubmed-meshheading:18291340-Organ Transplantation
pubmed:year	2008
pubmed:articleTitle	Leishmaniasis among organ transplant recipients.
pubmed:affiliation	Department of Clinical Sciences L Sacco, Section of Infectious Diseases and Immunopathology, University of Milan, Milan, Italy. spinello.antinori@unimi.it
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't