Linked Life Data

18289766

Source:http://linkedlifedata.com/resource/pubmed/id/18289766

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2008-3-17
pubmed:abstractText
It is well known that chronic ethyl alcohol (EtOH) consumption is capable to injure brain cells and to cause essential abnormalities in behavioral characteristics of animals addicted to alcohol. In this work we for the first time have shown that administration of aqueous solutions of hydrated C60 fullerenes (C60HyFn) with C60 concentration of 30nM as a drinking water during chronic alcoholization of rats (a) protects the tissues of central nervous system (CNS) from damage caused by oxidative stress with high efficacy, (b) prevents the pathological loss of both astrocytes (the main cells of CNS) and astrocytic marker, glial fibrillary acidic proteins (GFAP) and, as consequence, (c) due to their adaptogenic effects, C60HyFn significantly improves behavioral response and eliminates emotional deficits induced by chronic alcohol uptake. The wide range of beneficial biological effects, zero-toxicity, and efficacy even in super-small doses provide a rationale for the possible application of C60HyFn for the treatment of alcohol-induced encephalopathy as well as alcoholism prophylaxis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
246
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
158-65
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Nanostructures of hydrated C60 fullerene (C60HyFn) protect rat brain against alcohol impact and attenuate behavioral impairments of alcoholized animals.
pubmed:affiliation
Biophysics & Biochemistry Department, National University of Dniepropetrovsk, 49050 Dniepropetrovsk, Ukraine. artfullerene@gmail.com
pubmed:publicationType
Journal Article