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pubmed-article:18282769pubmed:abstractTextAttention-Deficit/Hyperactivity Disorder (ADHD) is highly prevalent among adolescents with Substance Use Disorders (SUD). Effects of methylphenidate (MPH) on ADHD are attributed to its properties of blocking the dopamine transporter (DAT) in the striatum. However, it has been demonstrated that drug addiction is associated with dopaminergic system changes that may affect MPH brain effects, emphasizing the need to better understand MPH actions in subjects with ADHD+SUD.lld:pubmed
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pubmed-article:18282769pubmed:articleTitleMethylphenidate DAT binding in adolescents with Attention-Deficit/ Hyperactivity Disorder comorbid with Substance Use Disorder--a single photon emission computed tomography with [Tc(99m)]TRODAT-1 study.lld:pubmed
pubmed-article:18282769pubmed:affiliationADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre (POA), Estado do Rio Grande do Sul (RS), Brasil. cmszobot@terra.combrlld:pubmed
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