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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-24
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pubmed:abstractText |
Attention-Deficit/Hyperactivity Disorder (ADHD) is highly prevalent among adolescents with Substance Use Disorders (SUD). Effects of methylphenidate (MPH) on ADHD are attributed to its properties of blocking the dopamine transporter (DAT) in the striatum. However, it has been demonstrated that drug addiction is associated with dopaminergic system changes that may affect MPH brain effects, emphasizing the need to better understand MPH actions in subjects with ADHD+SUD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1053-8119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1195-201
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pubmed:meshHeading |
pubmed-meshheading:18282769-Adolescent,
pubmed-meshheading:18282769-Attention Deficit Disorder with Hyperactivity,
pubmed-meshheading:18282769-Chemistry, Pharmaceutical,
pubmed-meshheading:18282769-Data Interpretation, Statistical,
pubmed-meshheading:18282769-Diagnosis, Dual (Psychiatry),
pubmed-meshheading:18282769-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:18282769-Dopamine Uptake Inhibitors,
pubmed-meshheading:18282769-Female,
pubmed-meshheading:18282769-Humans,
pubmed-meshheading:18282769-Image Processing, Computer-Assisted,
pubmed-meshheading:18282769-Male,
pubmed-meshheading:18282769-Methylphenidate,
pubmed-meshheading:18282769-Neostriatum,
pubmed-meshheading:18282769-Organotechnetium Compounds,
pubmed-meshheading:18282769-Protein Binding,
pubmed-meshheading:18282769-Psychiatric Status Rating Scales,
pubmed-meshheading:18282769-Radiopharmaceuticals,
pubmed-meshheading:18282769-Substance-Related Disorders,
pubmed-meshheading:18282769-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:18282769-Tropanes
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pubmed:year |
2008
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pubmed:articleTitle |
Methylphenidate DAT binding in adolescents with Attention-Deficit/ Hyperactivity Disorder comorbid with Substance Use Disorder--a single photon emission computed tomography with [Tc(99m)]TRODAT-1 study.
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pubmed:affiliation |
ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre (POA), Estado do Rio Grande do Sul (RS), Brasil. cmszobot@terra.combr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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