18276135

Source:http://linkedlifedata.com/resource/pubmed/id/18276135

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017262, umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0185117, umls-concept:C0205409, umls-concept:C0387583, umls-concept:C1533698, umls-concept:C2725360, umls-concept:C2911684
pubmed:issue	6
pubmed:dateCreated	2008-3-17
pubmed:abstractText	Three sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from Xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (IC(50) values: 0.47, 11.2, 136.5 microM, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-kappaB through the inhibition of LPS-induced I-kappaB-alpha degradation in microglia.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Furans, http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Kinase, http://linkedlifedata.com/resource/pubmed/chemical/Lactones, http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Sesquiterpenes, http://linkedlifedata.com/resource/pubmed/chemical/xanthatin, http://linkedlifedata.com/resource/pubmed/chemical/xanthinosin
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1464-3405
pubmed:author	pubmed-author:JeonRaokR, pubmed-author:KimHee-DooHD, pubmed-author:LeeHwa JinHJ, pubmed-author:LimHyo JinHJ, pubmed-author:RyuJae-HaJH, pubmed-author:YoonJeong HoonJH
pubmed:issnType	Electronic
pubmed:day	15
pubmed:volume	18
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2179-82
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:18276135-Animals, pubmed-meshheading:18276135-Cell Survival, pubmed-meshheading:18276135-Cells, Cultured, pubmed-meshheading:18276135-Chromatography, High Pressure Liquid, pubmed-meshheading:18276135-Cyclooxygenase 2, pubmed-meshheading:18276135-Furans, pubmed-meshheading:18276135-Gene Expression Regulation, Enzymologic, pubmed-meshheading:18276135-I-kappa B Kinase, pubmed-meshheading:18276135-Lactones, pubmed-meshheading:18276135-Lipopolysaccharides, pubmed-meshheading:18276135-Magnetic Resonance Spectroscopy, pubmed-meshheading:18276135-Mice, pubmed-meshheading:18276135-Microglia, pubmed-meshheading:18276135-NF-kappa B, pubmed-meshheading:18276135-Nitric Oxide Synthase Type II, pubmed-meshheading:18276135-RNA, Messenger, pubmed-meshheading:18276135-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:18276135-Sesquiterpenes, pubmed-meshheading:18276135-Xanthium
pubmed:year	2008
pubmed:articleTitle	Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium.
pubmed:affiliation	College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-Gil, Yongsan-Gu, Seoul 140-742, Republic of Korea.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't