18272305

Source:http://linkedlifedata.com/resource/pubmed/id/18272305

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006675, umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0025932, umls-concept:C0027651, umls-concept:C0033992, umls-concept:C0079189, umls-concept:C0392747, umls-concept:C0870883, umls-concept:C1280500, umls-concept:C1416433
pubmed:issue	1-2
pubmed:dateCreated	2008-4-8
pubmed:abstractText	In vivo studies of the effectiveness of various forms of calcium pterin reveal significant antitumor activity associated with (1:4, mol/mol) calcium pterin (CaPterin), (1:2, mol/mol) calcium pterin, dipterinyl calcium pentahydrate (DCP), as well as unexpectedly for a calcium chloride dihydrate solution in nude mice with MDA-MB-231 xenographs. Stepwise regression analysis of nine plasma cytokine and indoleamine 2,3-dioxygenase (IDO) metabolite levels identified four effects correlated to (1:4, mol/mol) calcium pterin administration: (1) decreased IL-6, (2) increased IL-10, (3) decreased IFN-gamma, and (4) increased kynurenine. CONCLUSION: (1:4, mol/mol) CaPterin exerts significant (by Spearman rank order correlation) dose-response antitumor activity in nude mice with MDA-MB-231 xenographs, and sustains both inflammatory and anti-inflammatory changes in the levels of certain plasma factors.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7804127
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Immunologic Factors, http://linkedlifedata.com/resource/pubmed/chemical/Indoleamine-Pyrrole 2,3,-Dioxygenase, http://linkedlifedata.com/resource/pubmed/chemical/Kynurenine, http://linkedlifedata.com/resource/pubmed/chemical/Pterins, http://linkedlifedata.com/resource/pubmed/chemical/Suspensions, http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0378-5173
pubmed:author	pubmed-author:DiPasqualeAntonio GAG, pubmed-author:FuchsDietmarD, pubmed-author:MohenoPhillipP, pubmed-author:PfleidererWolfgangW, pubmed-author:RheingoldArnold LAL
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	355
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	238-48
pubmed:meshHeading	pubmed-meshheading:18272305-Animals, pubmed-meshheading:18272305-Calcium, pubmed-meshheading:18272305-Cell Line, Tumor, pubmed-meshheading:18272305-Crystallography, X-Ray, pubmed-meshheading:18272305-Cytokines, pubmed-meshheading:18272305-Dose-Response Relationship, Drug, pubmed-meshheading:18272305-Humans, pubmed-meshheading:18272305-Immunologic Factors, pubmed-meshheading:18272305-Indoleamine-Pyrrole 2,3,-Dioxygenase, pubmed-meshheading:18272305-Kynurenine, pubmed-meshheading:18272305-Mice, pubmed-meshheading:18272305-Mice, Nude, pubmed-meshheading:18272305-Models, Molecular, pubmed-meshheading:18272305-Molecular Conformation, pubmed-meshheading:18272305-Pterins, pubmed-meshheading:18272305-Spectroscopy, Fourier Transform Infrared, pubmed-meshheading:18272305-Suspensions, pubmed-meshheading:18272305-Transplantation, Heterologous, pubmed-meshheading:18272305-Tryptophan
pubmed:year	2008
pubmed:articleTitle	Cytokine and IDO metabolite changes effected by calcium pterin during inhibition of MDA-MB-231 xenograph tumors in nude mice.
pubmed:affiliation	SanRx Pharmaceuticals, Inc., 603 Colima Street, La Jolla, CA 92037, USA. phil.moheno@sanrx.com
pubmed:publicationType	Journal Article