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pubmed-article:18268280pubmed:abstractTextbeta-thalassemia is one of the most common genetic diseases in the world and requires extensive therapy. Lentiviral-mediated gene therapy has been successfully exploited in the treatment of beta-thalassemia and showed promise in clinical application. Using a human beta-globin transgenic mouse line in a beta-thalassemia diseased model generated with a lentiviral-mediated approach, we investigate the stable therapeutic effect on a common thalassemia syndrome.lld:pubmed
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pubmed-article:18268280pubmed:articleTitleA novel transgenic mouse model produced from lentiviral germline integration for the study of beta-thalassemia gene therapy.lld:pubmed
pubmed-article:18268280pubmed:affiliationShanghai Institute of Medical Genetics, Shanghai Children's Hospital, Shanghai Jiaotong University School of Medicine, 1400/24 West Beijing Road, Shanghai, China.lld:pubmed
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