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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-3
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pubmed:abstractText |
beta-thalassemia is one of the most common genetic diseases in the world and requires extensive therapy. Lentiviral-mediated gene therapy has been successfully exploited in the treatment of beta-thalassemia and showed promise in clinical application. Using a human beta-globin transgenic mouse line in a beta-thalassemia diseased model generated with a lentiviral-mediated approach, we investigate the stable therapeutic effect on a common thalassemia syndrome.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:FuY PYP,
pubmed-author:GálE MEM,
pubmed-author:GongXiuliX,
pubmed-author:GuoXinbingX,
pubmed-author:HuangShuzhenS,
pubmed-author:RenZhaoruiZ,
pubmed-author:WangShuS,
pubmed-author:XieShuyangS,
pubmed-author:ZengFanyiF,
pubmed-author:ZengYitaoY,
pubmed-author:ZhangJingzhiJ
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pubmed:issnType |
Electronic
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
356-62
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pubmed:meshHeading |
pubmed-meshheading:18268280-Animals,
pubmed-meshheading:18268280-Bone Marrow,
pubmed-meshheading:18268280-Disease Models, Animal,
pubmed-meshheading:18268280-Female,
pubmed-meshheading:18268280-Gene Therapy,
pubmed-meshheading:18268280-Genetic Vectors,
pubmed-meshheading:18268280-Germ-Line Mutation,
pubmed-meshheading:18268280-Globins,
pubmed-meshheading:18268280-Humans,
pubmed-meshheading:18268280-Lentivirus,
pubmed-meshheading:18268280-Liver,
pubmed-meshheading:18268280-Male,
pubmed-meshheading:18268280-Mice,
pubmed-meshheading:18268280-Mice, Mutant Strains,
pubmed-meshheading:18268280-Mice, Transgenic,
pubmed-meshheading:18268280-Microinjections,
pubmed-meshheading:18268280-Mutagenesis, Insertional,
pubmed-meshheading:18268280-Recombinant Fusion Proteins,
pubmed-meshheading:18268280-Spleen,
pubmed-meshheading:18268280-Virus Integration,
pubmed-meshheading:18268280-beta-Thalassemia
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pubmed:year |
2008
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pubmed:articleTitle |
A novel transgenic mouse model produced from lentiviral germline integration for the study of beta-thalassemia gene therapy.
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pubmed:affiliation |
Shanghai Institute of Medical Genetics, Shanghai Children's Hospital, Shanghai Jiaotong University School of Medicine, 1400/24 West Beijing Road, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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